Evolution of multiple domains of the hiv-1 envelope glycoprotein during coreceptor switch with ccr5 antagonist therapy

HIGHLIGHTS

• who: Yueqi Du et al. from the Birmingham, Alabama, USAWashington University have published the research: Evolution of multiple domains of the HIV-1 envelope glycoprotein during coreceptor switch with CCR5 antagonist therapy, in the Journal: (JOURNAL) of 14/09/2022
• what: This study examined shift of HIV-1 from CCR5-tropic strains to CXCR4tropic or dual-tropic strains among five subjects in a clinical trial of the antagonist gene amplicon libraries were constructed and subjected to next-generation sequencing as well as single-clone sequencing and functional analyses. This work examines isolates obtained from subjects . . .
  

   

  

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