Corm-3 induces dna damage through ru(ii) binding to dna

HIGHLIGHTS

• who: Rhiannon F. Lyon and colleagues from the SchoolUniversity of have published the Article: CORM-3 induces DNA damage through Ru(II) binding to DNA, in the Journal: (JOURNAL) of 18/05/2022
• what: The authors show that the Ru(II) ion also binds to DNA, at exposed guanosine N7 positions. The authors focus on one of these, carbon monoxide releasing molecule 3 , Ru(CO)3Cl(glycinate), which was designed as a rapid water-soluble carbon monoxide-releasing molecule and has been widely used in cellular studies as a source of CO . Using an alkaline . . .
  

   

  

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