HIGHLIGHTS
- who: The Oncologist et al. from the Corresponding author:, MD, PhD, Department of Radiation Oncology, Heersink School of Medicine at University of Alabama at have published the research work: HiJAKing Immunotherapy-Resistant Melanoma for a Cure, in the Journal: (JOURNAL)
- what: The authors provide a on recent research endeavors concerning ICB resistance in melanoma patients. The authors demonstrate that loss of IFN-u03b3 signaling in melanoma hampers infiltration and functional rejuvenation of TILs, which in turn mediates ICB resistance.
SUMMARY
By releasing immune "brakes" (ie, CTLA-4, PD-1/L1) that . . .
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