Traf4 hyperactivates her2 signaling and contributes to trastuzumab resistance in her2-positive breast cancer

HIGHLIGHTS

• who: Yayun Gu from the (UNIVERSITY) have published the paper: TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer, in the Journal: (JOURNAL) of 21/07/2022
• what: The authors show that SMURF2 acts as an E3 ligase to inhibit HER2 receptor signaling. To summarize, the model the authors present (Fig 7) is that TRAF4 forms an E3 ligase complex with SMURF2, and this Ying-Yang TRAF4SMURF2 regulatory complex regulates HER2 through balancing its stability and activity.
• how: This result was further validated by colony formation analysis using . . .
  

   

  

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