HIGHLIGHTS
SUMMARY
The authors engineered genome-wide barcoded transposon libraries to measure the invasion fitness effects of all possible gene knockouts in the coexisting strains as well as their ancestor, for many different, ecologically relevant conditions. The authors found that the invasion fitness effects of many gene knockouts sensitively depends on the genetic background and the ecological conditions, as set by the abiotic environment and relative frequency of both ecotypes. After inferring the fitness effect of each gene knockout, the authors can compare fitness effects across genetic backgrounds and environments. Beneficial knockout fitness in REL606 is . . .
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