HIGHLIGHTS
SUMMARY
While a 17 gene leukemia stem_cell signature (LSC17) is predictive in the aggregated pediatric study population, LSC17 is no longer predictive within established cytogenetic and molecular (cytomolecular) risk groups. An AML study in adults previously identified 47 unique genes enriched in leukemia stem_cell populations (LSC47) and extracted an optimal 17 gene signature (LSC17) that was highly prognostic across five independent cohorts comprised of adult patients with diverse AML subtypes (n=908)11. The authors harnessed RNA-sequencing performed in diagnostic AML samples from 1,503 patients enrolled in one of four clinical trials (Fig . . .
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