HIGHLIGHTS
- who: Huiling Guo from the Our research complies with all relevant ethical regulations of Xiamen University and Fudan University have published the paper: Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system, in the Journal: (JOURNAL) of 16/Nov/2021
- what: The authors show that blocking the sorting system that directs EGFR to plasma_membrane is a potent strategy to treat EGFR-dependent tumors. To evaluate the therapeutic potential of this sorting system, the authors design a cell-permeable peptide, N-myristoylated GKVL-TAT, and find it effectively disrupts plasma_membrane localization of EGFR and . . .
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