Metformin alleviates neurocognitive impairment in aging via activation of ampk/bdnf/pi3k pathway

HIGHLIGHTS

  • who: Omnia Ameen from the DepartmentUniversity have published the paper: Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway, in the Journal: Scientific Reports Scientific Reports
  • what: The study showed that chronic administration of D-gal impaired novelty-induced exploratory behaviors and working memory in rats. In the present study, EPM test results showed increased anxiety-like behavior in the D-gal group when compared with the control group.
  • how: Thirty Wister albino male rats weighing 200-250 grams were used in the experiment after obtaining the necessary approvals . . .

     

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