Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences

HIGHLIGHTS

• who: Johannes C. S. Zang from the Thus, findings on the molecular level underscore the relevance of immune and stress response system dynamics, and make a strong case for studying the molecular consequences of adverse childhood experience within the context of acute stress processingPreviously, we observed differential gene expression patterns in monocytes following exposure to social stress, with increased activity of pro-inflammatory upstream signaling in a sample of healthy adults reporting childhood adversity [31]. Yet, although research on DNA methylation or transcriptomic profiles yielded valuable insights, it remains elusive to what extend childhood adversity is reflected . . .
  

   

  

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