Dna methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

HIGHLIGHTS

SUMMARY

Gestational diabetes_mellitus (GDM) is a common pregnancy-specific disease, characterized by glucose intolerance. Placenta shows genome‑wide methylation alterations associated with type II diabetes_mellitus in GDM patients DMRs are genomic regions with differential methylation status across multiple CpG sites, which are considered to play an important role in gene imprinting and regulating the expression of nearby genes that were called differentially methylated genes (DMGs). Interestingly, the "type II diabetes_mellitus" pathway was significantly enriched in hypo-DMGs (FDR=0.033), suggesting that GDM may have the epigenetic characteristics of type II diabetes_mellitus (Fig 1D). Examples . . .

 



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