Tgfβ pathway is required for viable gestation of fanconi anemia embryos

HIGHLIGHTS

• who: Alfredo Rodru00edguez and colleagues from the Universidad Nacional Autou0301noma de, Instituto have published the research work: TGFu03b2 pathway is required for viable gestation of Fanconi anemia embryos, in the Journal: (JOURNAL) of May/24,/2022
• what: The authors demonstrate that genetic disruption of Smad3 a transducer of the canonical TGFu03b2 pathway modifies the phenotype of FA mouse models deficient for Fancd2. The authors determined whether a cross between Fancd2 (an FA gene) and Smad3 (the canonical TGFu03b2 pathway transducer) heterozygous mice would generate double 1 / 27 __NEWPAGE__PLOS Funding: ADD is supported by the NIH . . .
  

   

  

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