Deletion of sm22α disrupts the structure and function of caveolae and t-tubules in cardiomyocytes, contributing to heart failure

HIGHLIGHTS

• who: Jun Wu et al. from the Medical University, Shijiazhuang, China, Department Physiology, College Basic Medicine have published the research work: Deletion of SM22u03b1 disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure, in the Journal: PLOS ONE of December/16,/2021
• what: The authors identified that the cardiomyocytes of SM22u03b1 KO mice displayed asynchronized SR Ca2+ release and abnormal contractile properties, accompanied with the disorganization of the plasma_membrane architecture, making the heart more vulnerable to pressure overload.
• how: This work was also supported by a . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.