Substrate-based design of cytosolic nucleotidase iiib inhibitors and structural insights into inhibition mechanism

HIGHLIGHTS

  • who: Dorota Kubacka and colleagues from the Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Address: RandD Centre, Celon Pharma SA, Marymoncka , Street, Kazunu0301 Nowy, Poland have published the article: Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism, in the Journal: Pharmaceuticals 2022, 554 of /2022/
  • what: The authors aimed to designed specific cN-IIIB inhibitors suitable for probing the function and regulating activity of cN-IIIB in cells. The lack of significant changes in the arrangement of catalytic_site suggested that the major reason . . .

     

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