Modulating gene regulation function by chemically controlled transcription factor clustering

HIGHLIGHTS

• who: Jiegen Wu from the Center forPeking University, Beijing, China have published the paper: Modulating gene regulation function by chemically controlled transcription factor clustering, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: To examine this, the authors focused on conditions where Kds are relatively stable while Hill coefficients are changing, i.e., between 5 nM and 30 nM rapamycin (Supplementary Figs 5e, f boxed region).
• how: At the level of transcriptional activation the authors presented spatiotemporal analyses of interactions between TF clusters and nascent transcription sites to illustrate the interactions between the two . . .
  

   

  

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