Overlapping gene dependencies for parp inhibitors and carboplatin response identified by functional crispr-cas9 screening in ovarian cancer

HIGHLIGHTS

• who: Ricardo Coelho from the (UNIVERSITY) have published the paper: Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer, in the Journal: (JOURNAL) of 26/04/2022
• what: To further verify this approach, the authors designed gRNAs against additional pan-essential genes AURKB, ERCC3, and PCNA . The authors focused on the response to the first clinically approved and widely used PARPi-olaparib . Most of the studies focused on the use of a class of inhibitors targeting multiple cyclin-dependent kinases (CDK)s suggesting that previously reported . . .
  

   

  

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