Intracellular marriage of bicarbonate and mn ions as “immune ion reactors” to regulate redox homeostasis and enhanced antitumor immune responses

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SUMMARY

    Recent studies suggest that M ­ n2+ would strongly promote immune_responses through proliferating cytotoxic T lymphocyte and promoting dendritic cell maturation. Flow cytometric analyses of the populations of_(G) matured DC cells and_(H) CD8 + T_cells and CD3 + T_cells in splenocytes of mice immunized after the different treatment (IL-6, IL-1α and TNF-α). Groups 1, 2, 3, 4, 5 and 6 were used to represent PBS, ­MnCO3-ICG ([Mn]: 2 mg/kg, four dose), 2 × ­MnCO3-ICG ([Mn]: 4 mg/kg, four dose), 4 × ­MnCO3-ICG ([Mn]: 8 mg/kg, four dose), ­MnCO3-ICG . . .

     

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