A multi-objective based clustering for inferring bcr clonal lineages from high-throughput b cell repertoire data

HIGHLIGHTS

SUMMARY

Identifying clonal lineage from high-throughput B cell repertoire data can help reconstruct cell lineage and unravel inter/intra clonal repertoire diversity. The sequences within each group are clustered according to some sequence-based A multi-objective clustering for B cell clonal lineage grouping distance. A multi-objective clustering for B cell clonal lineage grouping ai is the average distance between the sequence i and any other sequence in the same group K; bi is the smallest average distance of i to all sequences in any other group L The pure B cell lineage . . .

 



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