Establishment and identification of patient-derived xenograft model for oral squamous cell carcinoma

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SUMMARY

    Oral squamous cell carcinoma (OSCC) is the most common head and neck malignant tumor. Due to the heterogeneity of tumors and individual differences of patients, the current chemotherapy for solid tumors mainly relies on clinical experience and lacks individualized evaluation and drug guidance for tumor patients, resulting in the poor overall efficacy of chemotherapy. A patient-derived xenograft model (PDX model) is a xenograft model in which fresh tumor tissues from patients are directly transplanted onto immunodeficient mice, relying on the growth environment provided by the immunocompromised mice. This model can maintain various histological . . .

     

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