HIGHLIGHTS
- who: Siglec-F-expressing neutrophils are essential and colleagues from the LaboratoryNational University have published the article: profibrotic microenvironment in renal fibrosis, in the Journal: (JOURNAL)
- what: As a control for this experiment, the authors examined the renal parenchymal and vessel locations of neutrophils and macrophages of CD45 mAb-injected naive mice. This analysis showed that TGF-u03b21, GM-CSF, IL-23, and monocyte chemoattractant protein-1 (MCP-1) were rapidly upregulated soon after UUO . The authors report that a recently described Siglec-F-expressing neutrophil subset was elicited and strongly expanded in the fibrotic . . .
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