A genetic bottleneck of mitochondrial dna during human lymphocyte development

HIGHLIGHTS

  • who: Zhongjie Tang et al. from the State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China have published the article: A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development, in the Journal: (JOURNAL)
  • what: The authors focused on the human hematopoietic system, whose cellular differentiation lineages have been well documented. The authors focused on the B cell lineage, because T_cells mature in the thymus and their progenitors, pre-T_cells, are not present in PBMCs. This model has been widely used to model the mtDNA population dynamics in both . . .

     

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