Transcriptomic analysis reveals jak2/mpl-independent effects of calreticulin mutations in a c. elegans model

HIGHLIGHTS

• who: Ana Guijarro-Hernu00e1ndez and colleagues from the Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain have published the research: Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model, in the Journal: Cells 2022, 11, x FOR PEER REVIEW of /2022/
• what: To identify some of the aberrant mechanisms of mutant CALR proteins, in this study the authors performed whole-genome transcriptomic analyses in a C. elegans model harboring homozygous patient-like calreticulin mutations.

SUMMARY

Somatic mutations of CALR consist . . .

 



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