HIGHLIGHTS
- who: LARASATI, and Yonika, Arum from the parameters (duration, ps have published the article: Article Reference, in the Journal: (JOURNAL) of October/09,/2022
- what: Half of clinical cases affect codons Gly203 Arg209 or Glu246; the authors show that these mutations accelerate GTP uptake and inactivate GTP hydrolysis through displacement Gln205critical for GTP hydrolysis resulting in constitutive GTP binding by Gu03b1o. The work provides insights into the molecular etiology of GNAO1 encephalopathy and defines a potential therapy for the patients. As another control, the authors show that stimulation with the agonists without GPCR transfection does . . .
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