HIGHLIGHTS
- who: Yufei Wang from the (UNIVERSITY) have published the paper: The roles of osteoprotegerin in cancer, far beyond a bone player, in the Journal: (JOURNAL) of 22/04/2022
- what: Numerous literatures have detailed the functions of OPG in skeletal disease, but this topic is not the main focus of this review and can be referred to Kearns et_al .
SUMMARY
By binding to RANKL, OPG suppresses the maturation and activation of pre-osteoclasts via antagonizing RANK/RANKL signaling (Fig 2), thus inhibiting osteoclast function and promoting bone formation. Biochemically, full length . . .
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