HIGHLIGHTS
SUMMARY
Pakistan is the second largest HCV burden country in the world, with 4.5-8.2% HCV seroprevalence (Iqbal et_al, 2014; Umer and Iqbal, 2016). According to some studies, RASs in aa 93 (Y93H) are considered a >100 resistance foldchange NS5A RAS, especially when they appeared as a paired substitution with RASs in aa 30 in HCV 3a (Kjellin et_al, 2019; Smith et_al, 2019). Cirrhosis is an advance and critical condition of chronic HCV infection because it indicates a long-term viral infection Frontiers in Pharmacology | www.frontiersin.org April 2022 | Volume 13 | Article . . .
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