HIGHLIGHTS
SUMMARY
This event causes the increase of cell motility in_vitro and metastasis in_vivo in NSLC. Indeed, one study reported that the pro-apoptotic protein PUMA mediates the apoptosis induced by EGFR inhibitors in head and neck cancer cells, while another reported that the translocation of PUMA to the mitochondria can provoke cell death in lymphoma cells. This compound has antiproliferative effects in numerous cancer cells by inducing apoptosis in_vitro and in_vivo, hindering the angiogenic process, migration, and vasculogenic mimicry, including in GBM cell lines and primary GBM patient-derived cells. The authors observed that it . . .
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