Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine nk cell populations and dysregulated il-18 and htra1

HIGHLIGHTS

SUMMARY

The authors previously demonstrated that by GD18, P. gingivalis infection disrupts the physiologic remodeling of uterine spiral arteries characterized by reduced arterial lumen size, increased retention of spiral VSMC, and decreased extravillous trophoblast in the placental b ­ ed11. The degree of spiral artery remodeling was assessed by dilation of the arterial lumen, loss of the vascular smooth muscle cell (VSMC) layer, and invasion of the uterine tissue by extravillous ­trophoblasts20. Spiral arterial lumen size was significantly reduced in the infected group compared to controls | Vol:(1234567890) 12:14799 | Vascular necrosis with thrombosis was more . . .

 



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