HIGHLIGHTS
SUMMARY
The study of the role of neutrophils within the process of the initiation and progression of atherosclerosis and the development of complications have only been actively conducted over the past few years. Massena et_al identified a new subpopulation of circulating neutrophils expressing vascular endothelial growth factor receptor (VEGFR1, CD49d+VEGFR1highCXCR4highneutrophils) and constituting about 5% of the total pool of circulating neutrophils. In the VEGFRhigh ischemic tissue, neutrophils realize their proangiogenic effects in several known ways: secretion of VEGF-A contained in neutrophil granules, secretion of growth factor Bv8, and release of matrix metalloproteinase 9 . . .
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