HIGHLIGHTS
- who: Shuang Zhao from the (UNIVERSITY) have published the paper: Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors, in the Journal: (JOURNAL)
- what: Together, the authors provide new molecular insight into the function of Dppa3 in ES cells.
- how: IP-MS results showed that Dppa3 interacted with quite a few subunits of 26S proteasome. The results indicated that Dppa3 safeguard the stability of Uhrf1 and Nanog by inhibiting proteasomeassociated degradation in ES cells. The results showed that Dppa3 is involved in the regulation of protein stabilization (Fig 1B . . .
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