Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived ipscs

HIGHLIGHTS

• who: Ryu Kawada from the DepartmentKyoto University have published the article: Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs, in the Journal: Scientific Reports Scientific Reports
• what: The authors modified the previously used protocol for MyoD1-induced myogenic differentiation using hiPSCs and also investigated the in_vitro differentiation of CDH13-positive iMuSCs for DM1 disease modeling of skeletal muscles.
• how: In this study when conducting MBNL immunostaining the authors always used two fixation methods (PFA and acetone-MeOH) and the latter one . . .
  

   

  

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