HIGHLIGHTS
SUMMARY
In the era of Precision Medicine the factors affecting the minimal effective dose of any drug must be considered when treating patients. The lean body mass is a major determinant of thyroxine dose but, in clinical practice, the physicians usually choose the dose based on patient weight or BMI. The proof of concept of a relationship between the minimal effective dose of T4 and the actual gastric pH needs a direct assessment and this represented the aim of the study. Primary outcome of the study was to correlate pH values of fasting gastric acid . . .
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