Distinctive roles of translesion polymerases dinb1 and dnae2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

HIGHLIGHTS

• who: Pierre Dupuy from the (UNIVERSITY) have published the Article: Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis, in the Journal: (JOURNAL) of 17/03/2022
• what: The authors demonstrate that, when overexpressed, DinB1 promotes missense mutations conferring resistance to rifampicin, with a mutational signature distinct from that of DnaE2, and abets insertion and deletion frameshift mutagenesis in homo-oligonucleotide runs. The authors report that DinB1 can induce rifampicin resistance through a mutagenic activity. The study shows that DinB1 confers rifampicin resistance when the . . .
  

   

  

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