HIGHLIGHTS
- who: Antonio Lentini from the Karolinska Institute have published the article: Elastic dosage compensation by X-chromosome upregulation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
SUMMARY
Specifically, the conventional model of mammalian dosage compensation assumes an initial state of biallelically upregulated X chromosomes in female embryonic cells upon which XCI subsequently corrects the expression dosage by silencing one X allele. Disentangling the isolated dosage effects of XCU and XCI requires quantitative gene_expression measurements at a cellular and allelic resolution only recently enabled by allele-resolved single-cell RNA-seq (scRNA-seq), and computationally . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.