Chemogenetic profiling reveals pp2a‐independent cytotoxicity of proposed pp2a activators ihap1 and dt‐061

HIGHLIGHTS

• who: Vit et al. from the The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer have published the research: Chemogenetic profiling reveals PP2Au2010independent cytotoxicity of proposed PP2A activators iHAP1 and DTu2010061, in the Journal: (JOURNAL) of 18/05/2022
• what: The work provides insight into the biological pathways perturbed by iHAP1 and DT-061 causing cellular toxicity and argues that these compounds cannot be used for dissecting PP2AB56 biology. Collectively, the work shows that DT-061 has a clear and immediate effect on Golgi and ER integrity which impacts . . .
  

   

  

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