Research progress on mono-adp- ribosyltransferases in human cell biology

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SUMMARY

    ADP-Ribosylation ADP-ribosylation is a post-translational modification (PTM) process that is intrinsically associated with basal metabolic signaling pathways and has been recently identified as an essential regulator of DNA repair and cancer biology (Cohen and Chang, 2018; Crawford et_al, 2018). With advancements in the detection technology, ADP-ribosylation is no longer considered only as a protein modification, and these modifications have also been reported to occur onto phosphorylated nucleic_acids such as the ends of DNA and RNA (Dölle and Ziegler, 2017; Munnur et_al, 2019; Groslambert et_al, 2021; Weixler et_al, 2021). In . . .

     

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