Supt16 haploinsufficiency impairs pi3k/akt/mtor/autophagy pathway in human pluripotent stem cells derived neural stem cells

HIGHLIGHTS

  • who: Junwen Wang et al. from the Department of Medical Genetics, College of Basic Medical Science, Army Medical University (Third Medical University), Chongqing, China have published the paper: Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells, in the Journal: (JOURNAL)
  • what: The study has some shortcomings; the results obtained in animal models cannot be a complete substitute for studies in human models, and whether there is a pathogenic mechanism of Supt16 haploinsufficiency in human models remains to be further explored. The investigation showed that mTOR pathway . . .

     

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