HIGHLIGHTS
- who: Mara De Marco Zompit from the University of have published the article: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors propose that CIP2A-TOPBP1 complex formation is regulated during the cell cycle by nuclear export, which spatially sequesters CIP2A from TOPBP1 in interphase cells, thus allowing their efficient interaction exclusively in mitosis. The authors identified and characterized a highly conserved bi-partite protein interaction surface in TOPBP1 located between BRCT domains 5 and 6. The authors provide strong evidence that CIP2A and TOPBP1 . . .
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