HIGHLIGHTS
SUMMARY
V events by sequencing full-length transcripts (Bolisetty et_al, 2015; De Paoli-Iseppi et_al, 2021). The former makes read mapping near splice sites difficult (Tang et_al, 2020; Volden et_al, 2018; Weirather et_al, 2017), making it challenging to distinguish real splice junctions from mapping errors (Fig 1A). The key idea is to identify, for each splice junction, which of the squiggles predicted from potential splice junction sequences best matches the observed junction squiggle. This ‘squiggle matching` idea has been successfully applied to map raw signals to a reference genome (Loose et_al, 2016; Kovaka et_al, 2021 . . .
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