Hif-1 stabilization in t cells hampers the control of mycobacterium tuberculosis infection

HIGHLIGHTS

• who: Ruining Liu from the (UNIVERSITY) have published the paper: HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection, in the Journal: (JOURNAL) of 13/01/2022
• what: The authors show that mice lacking VHL in T_cells (Vhl cKO) are highly susceptible to infection with M. tuberculosis, which is associated with a low accumulation of mycobacteria-specific T_cells in the lungs that display reduced proliferation, altered differentiation and enhanced expression of inhibitory receptors.

SUMMARY

The authors show that mice lacking VHL in T_cells (Vhl cKO) are highly . . .

 



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