HIGHLIGHTS
- who: Martin Zirngibl from the (UNIVERSITY) have published the Article: Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination, in the Journal: (JOURNAL)
- what: With this review the authors provide an updated understanding of this model by showcasing two distinct yet overlapping modes of action for cuprizoneinduced demyelination; 1) damage originating from within the caused by mitochondrial dysfunction or reduced myelin protein synthesis. For this review, outside of these studies, unless stated otherwise, all other cuprizone research mentioned is carried out in mice . . .
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