HIGHLIGHTS
SUMMARY
The total EV population can be measured using their common membrane surface proteins, namely, CD9, CD63, and CD81 tetraspanins, even more accurately than with non-specific methods, such as the traditional nanoparticles tracking analysis (NTA) or protein quantification assays (e_g, bicinchoninic acid-based assay). Alongside the general membrane markers, EVs carry donor-cell specific proteins, e_g, epithelial_cell adhesion molecules (EpCAMs) that are overexpressed in some solid tumors and extensively investigated for active targeting by nanodrugs. To characterize the complexes of EVs with the antibody-functionalized magnetic nanoparticles (EV-anti-CD9-MP), the authors used . . .
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