Inhibition of glycolysis impairs retinoic acid-inducible gene i–mediated antiviral responses in primary human dendritic cells

HIGHLIGHTS

• who: Alessandra Zevini from the University of Tennessee Health Sciences Center, United States have published the Article: Inhibition of Glycolysis Impairs Retinoic Acid-Inducible Gene Iu2013Mediated Antiviral Responses in Primary Human Dendritic Cells, in the Journal: (JOURNAL)
• what: The authors demonstrate that DC increased their glycolytic rate in response to M8, and that glycolysis was an essential requirement for DC activation; pharmacological or genetic inhibition of M8 activity resulted in the failure of DC maturation and highly diminished antiviral defense. The authors demonstrate that inhibition of glycolysis in MoDCs impairs type I interferon signaling by . . .
  

   

  

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