Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse

HIGHLIGHTS

SUMMARY

    Alcohol memory reconsolidation depends on de novo gene transcription in the DH While it has been established that the reconsolidation of alcohol memories requires de novo protein synthesis, it remains unclear whether it is also dependent on de novo gene transcription. The authors assessed the role of gene transcription during alcohol memory reconsolidation within the DH, a brain region implicated in alcohol use disorder and involved in drug memory formation, retention, and expression, in addition to memory reconsolidation. To assess the role of hippocampal gene transcription in alcohol memory reconsolidation, the authors formed alcohol . . .

     

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