Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

HIGHLIGHTS

• who: Marta Varela-Eiru00edn from the (UNIVERSITY) have published the Article: Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression, in the Journal: (JOURNAL)
• what: The authors show that Cx43 is upregulated in sEVs released by OACs from patients. The authors demonstrate that exosomal Cx43 changes the protein cargo in sEVs, and plays a dual role by activating senescence and dedifferentiation in joint target cells, contributing to the spread and progression of the disease. The study was conducted with the approval of the institutional ethics . . .
  

   

  

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