Construction and characterization of a contagious ecthyma virus double-gene deletion strain and evaluation of its potential as a live-attenuated vaccine in goat

HIGHLIGHTS

  • who: Zhen Zhu from the (USDA), United States have published the Article: Construction and characterization of a contagious ecthyma virus double-gene deletion strain and evaluation of its potential as a live-attenuated vaccine in goat, in the Journal: (JOURNAL)
  • what: The aim of this study is to construct a genetically stable attenuated ORFV mutant that can be used as a safer and efficient vaccine candidate strain by deleting genes presumably involved in ORFV immunomodulatory properties. In the safety experiment, slight fever and anorexia were observed at 3 days post-infection leading to the increase . . .

     

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