HIGHLIGHTS
- who: . et al. from the Applied BioMath, United States York University, United States have published the Article: PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer, in the Journal: (JOURNAL)
- what: The aim of the research was to develop a mechanistic mathematical model to enhance the quantitative understanding for pharmacokinetics and pharmacodynamics of tau antibodies in animals and humans. For the study only one site was used for ISF collection.
- how: The following target binding equations were introduced into the model to describe the interaction between antibody . . .
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