HIGHLIGHTS
- who: Jonas P. Becker from the Cordeliers (CRC) (INSERM), France have published the Article: The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies, in the Journal: (JOURNAL)
- what: As not all presented tumor-specific epitopes trigger the necessary T_cell activation, recent modeling approaches focused on the prediction of immunogenicity based on peptide presentation and recognition characteristics or by structural modeling of HLA:peptide and HLA:peptide:TCR complexes .
- future: More recently the introduction of library-free approaches and tools for in silico prediction of mass spectra have enabled comparable . . .
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