HIGHLIGHTS
SUMMARY
Rodent studies have provided proof-of-concept using different cell types and models (reviewed by Duncan and amp; Valenzuela ), and a single Phase I clinical trial of direct brain injection of mesenchymal stromal cells (MSCs) found the procedure was safe but of no therapeutic consequence. Approximately 4-5 weeks post the first procedure, during which the SKN cells were manufactured, each patient underwent hippocampal microinjection of their autologous skin-derived neural precursor cells (SKNs) under general anaesthesia ("second procedure"). Rodent model of canine SKN cell engraftment Use of genetically non-modified autologous cells meant . . .
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