Structural dynamics in the evolution of sars-cov-2 spike glycoprotein

HIGHLIGHTS

• who: Valeria Calvaresi from the (UNIVERSITY) have published the research: Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein, in the Journal: (JOURNAL) of 15/02/2023
• what: The authors show that the RBD-associated subdomain plays a role in spike opening, whereas the NTD acts as a hotspot of conformational divergence of VOC spikes driving immune evasion. The authors demonstrate that spikes of alpha, beta and delta variants assume predominantly open receptor-accessible states and that the binding to ACE2 increases the dynamics of their S2 core helices, priming spikes for fusion . . .
  

   

  

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