Lpa disruption with aav-crispr potently lowers plasma apo(a) in transgenic mouse model: a proof-of-concept study

HIGHLIGHTS

• who: Alexandria M. Doerfler from the College Rice University of Medicine and Dentistry, London, ON N A , Canada have published the research: LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study, in the Journal: (JOURNAL) of 27/Dec/2022
• what: This work shows that liver-directed genome editing with CRISPR-Cas9 can effectively lower apo(a) levels, and highlights the importance of surveillance for unintended editing events within highly repetitive genes and globally within the genome. Given the highly repetitive nature of KIV domains in . . .
  

   

  

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