HIGHLIGHTS
SUMMARY
The hematogenous route is characterised by higher IFN-γ response gene_expression and a higher fraction of exhausted CD8+ T_cells. Previous studies have shown that IFN-γ upregulates the checkpoint inhibitor PD-L1 and cooperates with PD-1 to exhaust T_cells, thus suppressing the antitumour immune_response53,54. The authors hypothesise that the immune microenvironment of primary tumour of the hematogenous route should be present with more exhausted T_cells, which is convenient for tumour cell dissemination. According to specific genes of different immune cell types (Supplementary Fig 6c), the authors observed distinct clusters for B cells, CD4+ T_cells . . .
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